This is a classic Damn Interesting article which was originally published on 28 January 2006.
In the USA and other developed countries, cancer is presently responsible for about 25% of all deaths. The human immune system employs a network of microscopic sentries to watch for all manner of diseases, including the malformed, rapidly-dividing cells which make up cancer. But sometimes the immune system’s somewhat lackadaisical response to cancer cells allows the rogue cells to overwhelm the immune system, posing a deadly threat to the body.
Conventional cancer treatments such as chemotherapy and radiation therapy can injure and kill these tumor cells, but with an inevitable degree of collateral damage. By way of example, chemotherapy has a therapeutic index of six to one, meaning that one healthy cell is killed for every six cancer cells which are destroyed. Given that tumors can be made up of millions of cells, the incidental damage caused by chemotherapy is considerable. Radiation therapy has the same drawback.
Clearly these radiation and specialized-poison therapies are highly indiscriminate treatments, but they are the best that modern medicine’s cancer-fighting toolbox has to offer. But science is working hard to develop an army of microscopic agents which can hunt down and destroy cancer cells with decisive prejudice: antitumor viruses.
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