“I don’t think I feel things the same way you do.”

The man sits at the table in the well-fitted attire of success—charming, witty, and instantly likeable. He is a confident, animated speaker, but he seems to be struggling with this particular point.

“It’s like… at my first job,” he continues, “I was stealing maybe a thousand bucks a month from that place. And this kid, he was new, he got wise. And he was going to turn me in, but before he got the chance I went to the manager and pinned the whole thing on him.” Now he is grinning widely. “Kid lost his job, the cops got involved, I don’t know what happened to him. And I guess something like that is supposed to make me feel bad, right? It’s supposed to hurt, right? But instead, it’s like there’s nothing.” He smiles apologetically and shakes his head. “Nothing.”

His name is Frank, and he is a psychopath.

In the public imagination, a “psychopath” is a violent serial killer or an over-the-top movie villain, as one sometimes might suspect Frank to be. He is highly impulsive and has a callous disregard for the well-being of others that can be disquieting. But he is just as likely to be a next-door neighbor, a doctor, or an actor on TV—essentially no different from anyone else who holds these roles, except that Frank lacks the nagging little voice which so profoundly influences most of our lives. Frank has no conscience. And as much as we would like to think that people like him are a rare aberration, safely locked away, the truth is that they are more common than most would ever guess.

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“I don’t remember things,” Henry explained to the unfamiliar female interviewer. She seemed very curious about how he spends a typical day, and about what he had eaten for breakfast, but his efforts to summon the information from his mind were fruitless. He could easily answer her questions regarding his childhood and early adult years, but the indefinite expanse of time since then was bereft of memories. In fact, from moment to moment Henry feels almost as though he has just awakened from a deep sleep, with the fleeting remnants of a dream always just beyond his grasp. Each experience, dull or dramatic, evaporates from his memory within a few dozen heartbeats and leaves no trace.

For over fifty years Henry has lived with anterograde amnesia, a form of profound memory loss which prevents new events from reaching his long-term memory. As a result his only memories are those he possessed prior to his amnesia, and the small window of moments immediately preceding the present.

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In the year 1760, a Swiss naturalist named Charles Bonnet became concerned when his grandfather Charles Lullin began to experience a parade of “amusing and magical visions.” The eighty-nine-year-old Lullin was being visited by visions of people, birds, carriages, and buildings, all of which were invisible to everyone but him. Apparently these mysterious objects materialized spontaneously among the few bits of the world he was still able to perceive through his cataracts.

Bonnet’s grandfather did not demonstrate any other signs of marble loss, in fact he seemed quite sane aside from the vivid hallucinations. Moreover, the elderly man was keenly aware that the strange sights were all in his mind. Bonnet cataloged his grandfather’s curious circumstances, and over time the condition he described came to be known as Charles Bonnet Syndrome, or CBS. Numerous similar cases have been recorded in the decades since, and though it has long been regarded as a rare disease, recent evidence suggests that it is much more widespread than previously believed.

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At the base of the human brain there lies a tiny organ called the pituitary gland. About the size of a pea, this demure little gland produces and secretes a cocktail of hormones into the bloodstream from its bony nook inside the skull, helping the body to govern many internal systems. The pituitary is perhaps most well-known for its production of the amino acid protein somatotropin, a growth hormone which stimulates cell reproduction and bodily development.

This humble chemical factory typically produces some amount of growth hormone throughout an individual’s life, though the volume usually drops off precipitously after adolescence. In spite of its small size, however, misbehaving pituitaries have been known to cause massive consequences for their owners.

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Imagine, if you will, that one by one your friends and family– the people closest to you– are being removed and replaced with exact duplicates. Although they are identical in appearance and manner, you are certain that these people are not your loved ones. They are impostors. While most people would become deeply paranoid in such a scenario, there are some individuals who experience such things every day without fear… and just wonder, “why?” Such is the life of people stricken with Capgras’ Syndrome.

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From childhood, we are taught that the human body has five senses. I’m sure we can all recite them: sight, hearing, touch, taste, and smell. This list has remained unchanged since the time of Aristotle. To most people, a “sixth sense” refers either to one outside the realm of the scientific, or one that simply does not exist in most humans.

However, ask a neurologist how many senses the human body has, and you might get a surprising answer. Many identify nine or more senses- some listing as many as twenty-one. The first category of senses is the “special” senses, including the familiar sight, hearing, taste, and smell. The second category is made up of the somatic senses, which we usually lump under “touch”- including our perception of pressure, heat, and pain. The third category, however, is not nearly as well-known. These are the interoceptive senses- those that deal with data originating in the body itself.

It is fairly obvious what happens to a person when a sense fails. Many members of society are missing one or more senses. It is common knowledge that blindness is the absence of sight. Deafness, of hearing. Everyone knows what it’s like to lose taste and smell as well; this loss accompanies every head cold. But what happens when the body loses knowledge of itself is a far stranger occurrence.

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Beginning as early as 1916, and continuing well into the 1920s, an unusual and disturbing illness devastated millions of people throughout the world. It arrived in the shadow of the 1918 Spanish Flu epidemic– which killed an estimated fifty million people worldwide– so it has been largely overlooked by history despite the fact that it took the lives of over a million people, and left countless others frozen inside unresponsive bodies.

Young people, particularly women, were the most vulnerable to the disease, though it affected people of all ages. When an individual was stricken, the first signs were typically a sore throat and fever accompanied by a headache; but these discomforts soon developed into more alarming problems such as double-vision and severe weakness. Within hours, most of the victims were gripped by episodes of tremors, strange bodily movements, intense muscle pains, and delayed mental response. Symptoms rapidly increased in severity, and in spite of medical attention, most patients worsened dramatically. Behavioral changes often appeared– including psychosis and hallucinations– followed by steadily increasing drowsiness and lethargy. Many became comatose and completely unresponsive.

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When the human ear encounters music, a number of brain systems are engaged by the incoming sound. The music signal is first directed to the thalamus, which relays the information to the primary auditory cortex. Once activated, this part of the brain is thought to identify the fundamental elements of the music, such as pitch and loudness. The secondary auditory cortex then processes the harmony, melody and rhythmic patterns, and the tertiary auditory cortex seems to integrate everything into the overall experience of music. Such is the process to the best of modern science’s understanding, but the complex mental digestion of music is not yet fully understood.

Equally difficult to explain is a strange phenomenon known as “musical hallucinations” which is a condition very similar to having a song stuck in one’s head; but the music is considerably more true-to-life, it is heard almost non-stop, and it is practically impossible to ignore.

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