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	<title>Comments on: The Sleeping Sickness</title>
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		<title>By: ily_lisy</title>
		<link>http://www.damninteresting.com/the-sleeping-sickness/#comment-26337</link>
		<dc:creator>ily_lisy</dc:creator>
		<pubDate>Sun, 28 Nov 2010 23:45:42 +0000</pubDate>
		<guid isPermaLink="false">http://www.damninteresting.com/?p=627#comment-26337</guid>
		<description>I hope someone responds to this....but what has happened to the people treated with the L-Dopa since 1969?</description>
		<content:encoded><![CDATA[<p>I hope someone responds to this&#8230;.but what has happened to the people treated with the L-Dopa since 1969?</p>
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		<title>By: pikespeakdave</title>
		<link>http://www.damninteresting.com/the-sleeping-sickness/#comment-23999</link>
		<dc:creator>pikespeakdave</dc:creator>
		<pubDate>Tue, 17 Feb 2009 03:57:59 +0000</pubDate>
		<guid isPermaLink="false">http://www.damninteresting.com/?p=627#comment-23999</guid>
		<description>I have watched Awakenings a few different times, it is one of my favorites, because it is filled with so much detail.

I have been living with YOPD for 13 years, and the medicine the patients received in the clinic was L-dopa, a precuror to sinement that is considered a gold standard of PD treatment for many patients with this chronic condition. And the simarilities to the reaction of the patients is strikingly similiar. If you take to much Sinement (Carbidopa/Levodopa) you experience erratic body movements, and issue of mania and other side effects. 

But, Flu Epidemic and sleeping Sickness followed right WWI, where many chemical agents were used as weopans in large nnumbers. And PD has a similiar distinction that it first discovered at the beginng of the Industrial age in 1817 by a london doctor named James Parkinsons who wrote an essay called Shaking Palsy.

In Baltimore and in Northern California a few men had developed a new derivative of heroin which caused instant paralys after using this drug. The Clinical drug is now called MPTP, which is now used to study ways to develop treatments for PD using animals to try new treatments.

Consudering PD is thought to be caused by the loss of the chemical Dopamine in the brain, 

But. the movie starts out with some interresting clues about how this disease started in a young boy, He is described by jis mother as an avid reader and was a good student, but the mother and one of  his teachers noticed that is writing became harder to read because of his writing necame smaller in print, and eventually succumbed to one morning his mother was unable to wake him. He was sent to hospital where he spent in a comatose state for many years. 

The Doctor, Oliver Sacks was sent to this hospital that had many patients that suffered from this condition, and one morning he noticed one lady who could barely move caught her glasses in her hands before they hit the floor. So in some ways the brain is able to function, but the body is frozen in place.

The Young Man is given the first trial of L-dopa, and after increasing the dose to a sufficient level, he awakens and returns to almost normal state, but he still acts as a young teenager although he is in his late 40&#039;s or early 50&#039;s. They wventually get approval from the medical board to try to awaken the rest of these patients, Such a wild scene, one moment tou have many patients unable to move, and slowly the place is pure bedlam. All these patients think it is the year they were first struck with this condition, although in most cases many years has been lost. 

Examples of touch, music, changing environment like the floor pattern, and dancing and other therapies made as much difference to these people&#039;s lives as well as the medicine.

But, more medicine was needed to keep these patients active, which caused many sad side effect that were in physical, and physcological in nature, and the young man was returned to comatose state, just like the rest of them. 

The movie ends, but because of this doctor&#039;s observations, he made the biggest advance in PD treatment that in the field of medical field has not been repeated since then.

Do I think another repeat of sleeping sickness or an epidemic of increased cases of PD in the future, YES.

Just look what Crystal Meth does, or why in America, the fastest growing group of PD patients in America are the migrant workers that work in the fields of California picking our produce, And China isn&#039;t exactly have a stellar image on environmental issues. And the battlefield of Iraq may be another place.

But, I hope I am wrong, but Bush hasn&#039;t been very good advocate for medical research and he sure has no conscience on social issues either.

Davud W Walker</description>
		<content:encoded><![CDATA[<p>I have watched Awakenings a few different times, it is one of my favorites, because it is filled with so much detail.</p>
<p>I have been living with YOPD for 13 years, and the medicine the patients received in the clinic was L-dopa, a precuror to sinement that is considered a gold standard of PD treatment for many patients with this chronic condition. And the simarilities to the reaction of the patients is strikingly similiar. If you take to much Sinement (Carbidopa/Levodopa) you experience erratic body movements, and issue of mania and other side effects. </p>
<p>But, Flu Epidemic and sleeping Sickness followed right WWI, where many chemical agents were used as weopans in large nnumbers. And PD has a similiar distinction that it first discovered at the beginng of the Industrial age in 1817 by a london doctor named James Parkinsons who wrote an essay called Shaking Palsy.</p>
<p>In Baltimore and in Northern California a few men had developed a new derivative of heroin which caused instant paralys after using this drug. The Clinical drug is now called MPTP, which is now used to study ways to develop treatments for PD using animals to try new treatments.</p>
<p>Consudering PD is thought to be caused by the loss of the chemical Dopamine in the brain, </p>
<p>But. the movie starts out with some interresting clues about how this disease started in a young boy, He is described by jis mother as an avid reader and was a good student, but the mother and one of  his teachers noticed that is writing became harder to read because of his writing necame smaller in print, and eventually succumbed to one morning his mother was unable to wake him. He was sent to hospital where he spent in a comatose state for many years. </p>
<p>The Doctor, Oliver Sacks was sent to this hospital that had many patients that suffered from this condition, and one morning he noticed one lady who could barely move caught her glasses in her hands before they hit the floor. So in some ways the brain is able to function, but the body is frozen in place.</p>
<p>The Young Man is given the first trial of L-dopa, and after increasing the dose to a sufficient level, he awakens and returns to almost normal state, but he still acts as a young teenager although he is in his late 40&#8242;s or early 50&#8242;s. They wventually get approval from the medical board to try to awaken the rest of these patients, Such a wild scene, one moment tou have many patients unable to move, and slowly the place is pure bedlam. All these patients think it is the year they were first struck with this condition, although in most cases many years has been lost. </p>
<p>Examples of touch, music, changing environment like the floor pattern, and dancing and other therapies made as much difference to these people&#8217;s lives as well as the medicine.</p>
<p>But, more medicine was needed to keep these patients active, which caused many sad side effect that were in physical, and physcological in nature, and the young man was returned to comatose state, just like the rest of them. </p>
<p>The movie ends, but because of this doctor&#8217;s observations, he made the biggest advance in PD treatment that in the field of medical field has not been repeated since then.</p>
<p>Do I think another repeat of sleeping sickness or an epidemic of increased cases of PD in the future, YES.</p>
<p>Just look what Crystal Meth does, or why in America, the fastest growing group of PD patients in America are the migrant workers that work in the fields of California picking our produce, And China isn&#8217;t exactly have a stellar image on environmental issues. And the battlefield of Iraq may be another place.</p>
<p>But, I hope I am wrong, but Bush hasn&#8217;t been very good advocate for medical research and he sure has no conscience on social issues either.</p>
<p>Davud W Walker</p>
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		<title>By: Radiatidon</title>
		<link>http://www.damninteresting.com/the-sleeping-sickness/#comment-23731</link>
		<dc:creator>Radiatidon</dc:creator>
		<pubDate>Tue, 13 Jan 2009 19:30:55 +0000</pubDate>
		<guid isPermaLink="false">http://www.damninteresting.com/?p=627#comment-23731</guid>
		<description>[quote]Jocelyn said: &quot;I noticed that there haven&#039;t been many entries for a while, but I&#039;m hoping that somebody may read this and help.  I was diagnosed with encephalitis lethargica when I was 5 in 1978.  My parents were told to start making arrangements for my funeral.  I made it through, however I want to know if anybody knows of the different prognosis for this disease.&quot;[/quote]

I’m not sure what you wish to know.  The disease you suffered from as a child was basically swelling of your brain due to an infection from a virus or bacterium.  Chances were that you had the Chicken Pox or a cold sore (herpes simplex) and the virus transverse the blood brain barrier infecting the cerebral tissue.  This will cause swelling of the brain tissue within the tight confines of the skull.

At this point the brain’s functions are impaired causing a variety of symptoms.  The more common ones due to a minor infection would be fever, loss of energy, little or no appetite, and a general overall sick feeling.

In more sever cases you have high fever, extreme sensitivity to light, a form of motion sickness causing nausea &amp; vomiting, extremely painful headaches, stiff neck, general confusion &amp; forgetfulness, seizures, and lethargic (sleepiness and/or unconsciousness).

Not something to take mildly, the infected should be monitored.  Understand that the disease itself is not contagious, only the virus or bacterium that caused it is.  Plus you can only suffer the symptoms if the virus or bacterium is able to cross your brain blood barrier and infect the brain tissue, and that is rare.

Thus you could contract the disease the caused the Encephalitis in sick individual, but it is very doubtful that it will cause you to suffer Encephalitis.

Anyway the longer the brain is swelled, and the amount of swelling is causing damage to the sensitive tissues.  Also a high fever is literally cooking the brain tissue.  Both are capable of creating debilitating brain damage.  

A person who survives a sever case could have speech problems, muscle coordination loss, blindness or decreased vision, learning disabilities, seizures, etc.

If you are suffering from some aftereffect, the only person who might be able to help with that would be a neurologist.  Then again it depends of the type of brain damage and the severity.

The Don.</description>
		<content:encoded><![CDATA[<p>[quote]Jocelyn said: &#8220;I noticed that there haven&#8217;t been many entries for a while, but I&#8217;m hoping that somebody may read this and help.  I was diagnosed with encephalitis lethargica when I was 5 in 1978.  My parents were told to start making arrangements for my funeral.  I made it through, however I want to know if anybody knows of the different prognosis for this disease.&#8221;[/quote]</p>
<p>I’m not sure what you wish to know.  The disease you suffered from as a child was basically swelling of your brain due to an infection from a virus or bacterium.  Chances were that you had the Chicken Pox or a cold sore (herpes simplex) and the virus transverse the blood brain barrier infecting the cerebral tissue.  This will cause swelling of the brain tissue within the tight confines of the skull.</p>
<p>At this point the brain’s functions are impaired causing a variety of symptoms.  The more common ones due to a minor infection would be fever, loss of energy, little or no appetite, and a general overall sick feeling.</p>
<p>In more sever cases you have high fever, extreme sensitivity to light, a form of motion sickness causing nausea &amp; vomiting, extremely painful headaches, stiff neck, general confusion &amp; forgetfulness, seizures, and lethargic (sleepiness and/or unconsciousness).</p>
<p>Not something to take mildly, the infected should be monitored.  Understand that the disease itself is not contagious, only the virus or bacterium that caused it is.  Plus you can only suffer the symptoms if the virus or bacterium is able to cross your brain blood barrier and infect the brain tissue, and that is rare.</p>
<p>Thus you could contract the disease the caused the Encephalitis in sick individual, but it is very doubtful that it will cause you to suffer Encephalitis.</p>
<p>Anyway the longer the brain is swelled, and the amount of swelling is causing damage to the sensitive tissues.  Also a high fever is literally cooking the brain tissue.  Both are capable of creating debilitating brain damage.  </p>
<p>A person who survives a sever case could have speech problems, muscle coordination loss, blindness or decreased vision, learning disabilities, seizures, etc.</p>
<p>If you are suffering from some aftereffect, the only person who might be able to help with that would be a neurologist.  Then again it depends of the type of brain damage and the severity.</p>
<p>The Don.</p>
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		<title>By: Jocelyn</title>
		<link>http://www.damninteresting.com/the-sleeping-sickness/#comment-23730</link>
		<dc:creator>Jocelyn</dc:creator>
		<pubDate>Tue, 13 Jan 2009 18:34:59 +0000</pubDate>
		<guid isPermaLink="false">http://www.damninteresting.com/?p=627#comment-23730</guid>
		<description>I noticed that there haven&#039;t been many entries for a while, but I&#039;m hoping that somebody may read this and help.  I was diagnosed with encephalitis lethargica when I was 5 in 1978.  My parents were told to start making arrangements for my funeral.  I made it through, however I want to know if anybody knows of the different prognosis for this disease.</description>
		<content:encoded><![CDATA[<p>I noticed that there haven&#8217;t been many entries for a while, but I&#8217;m hoping that somebody may read this and help.  I was diagnosed with encephalitis lethargica when I was 5 in 1978.  My parents were told to start making arrangements for my funeral.  I made it through, however I want to know if anybody knows of the different prognosis for this disease.</p>
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		<title>By: BenKinsey</title>
		<link>http://www.damninteresting.com/the-sleeping-sickness/#comment-22737</link>
		<dc:creator>BenKinsey</dc:creator>
		<pubDate>Tue, 16 Sep 2008 13:28:58 +0000</pubDate>
		<guid isPermaLink="false">http://www.damninteresting.com/?p=627#comment-22737</guid>
		<description>[quote]Cathryn said: &quot;i dont think any of them are.&quot;[/quote]
[quote]Cathryn said: &quot;you guys are so wrong.&quot;[/quote]
[quote]Cathryn said: &quot;me too. how unsensitive.&quot;[/quote]

Three comments=an overreaction  haha lightn up woman then go make me dinner...just playin

[quote]Tapion said: &quot;What if your patient 0, the one responsible for the millions of deaths, you passed it on to them, how would you feel. Knowing that your the one who killed millions of inocent lives.&quot;
Luckily you&#039;d be dead already so you wouldn&#039;t know the devastation you caused.</description>
		<content:encoded><![CDATA[<p>[quote]Cathryn said: &#8220;i dont think any of them are.&#8221;[/quote]<br />
[quote]Cathryn said: &#8220;you guys are so wrong.&#8221;[/quote]<br />
[quote]Cathryn said: &#8220;me too. how unsensitive.&#8221;[/quote]</p>
<p>Three comments=an overreaction  haha lightn up woman then go make me dinner&#8230;just playin</p>
<p>[quote]Tapion said: &#8220;What if your patient 0, the one responsible for the millions of deaths, you passed it on to them, how would you feel. Knowing that your the one who killed millions of inocent lives.&#8221;<br />
Luckily you&#8217;d be dead already so you wouldn&#8217;t know the devastation you caused.</p>
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		<title>By: Mirage_GSM</title>
		<link>http://www.damninteresting.com/the-sleeping-sickness/#comment-22370</link>
		<dc:creator>Mirage_GSM</dc:creator>
		<pubDate>Mon, 04 Aug 2008 13:11:32 +0000</pubDate>
		<guid isPermaLink="false">http://www.damninteresting.com/?p=627#comment-22370</guid>
		<description>@Tapion:
Way to go taking an extreme worst-case szenario and taking it to this...
Maybe your look on life is not quite as jolly as it ought to be?
Seriously, if you were serious about what you wrote, you should seek help. A friend to talk to or if that doesn&#039;t help a professional.</description>
		<content:encoded><![CDATA[<p>@Tapion:<br />
Way to go taking an extreme worst-case szenario and taking it to this&#8230;<br />
Maybe your look on life is not quite as jolly as it ought to be?<br />
Seriously, if you were serious about what you wrote, you should seek help. A friend to talk to or if that doesn&#8217;t help a professional.</p>
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		<title>By: Johh</title>
		<link>http://www.damninteresting.com/the-sleeping-sickness/#comment-20990</link>
		<dc:creator>Johh</dc:creator>
		<pubDate>Thu, 17 Apr 2008 02:54:14 +0000</pubDate>
		<guid isPermaLink="false">http://www.damninteresting.com/?p=627#comment-20990</guid>
		<description>[quote]SammieRockes said: &quot;Where exactly did this epidemic take place?  Was it in Spain?  Or the US?  I know there is one in Africa but which one is this!!!!!&quot;[/quote]

You might want to read the first sentence of the article, Sammie.</description>
		<content:encoded><![CDATA[<p>[quote]SammieRockes said: &#8220;Where exactly did this epidemic take place?  Was it in Spain?  Or the US?  I know there is one in Africa but which one is this!!!!!&#8221;[/quote]</p>
<p>You might want to read the first sentence of the article, Sammie.</p>
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		<title>By: SammieRockes</title>
		<link>http://www.damninteresting.com/the-sleeping-sickness/#comment-19985</link>
		<dc:creator>SammieRockes</dc:creator>
		<pubDate>Wed, 13 Feb 2008 15:21:46 +0000</pubDate>
		<guid isPermaLink="false">http://www.damninteresting.com/?p=627#comment-19985</guid>
		<description>Where exactly did this epidemic take place?  Was it in Spain?  Or the US?  I know there is one in Africa but which one is this!!!!!</description>
		<content:encoded><![CDATA[<p>Where exactly did this epidemic take place?  Was it in Spain?  Or the US?  I know there is one in Africa but which one is this!!!!!</p>
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		<title>By: Tapion</title>
		<link>http://www.damninteresting.com/the-sleeping-sickness/#comment-19297</link>
		<dc:creator>Tapion</dc:creator>
		<pubDate>Mon, 07 Jan 2008 09:55:01 +0000</pubDate>
		<guid isPermaLink="false">http://www.damninteresting.com/?p=627#comment-19297</guid>
		<description>I watched a show about how the 1918 Flu Pandemic and Encephalitis lethargica  may be connected. It said the Encephalitis lethargica struck those that had the Spanish Flu but survived it. A huge Quarentine effort was put into effect in Sombolia and Encephalitis lethargica never showed up in that area but everywhere else it did. Also, it said the the Spanish Flu Pandemic rose hell on the same day in four different parts of the globe and vanished just as quick everywhere on the same day (in a different year of course). Pretty scary, almost seems like something out of this world. The reason they say Encephalitis lethargica is connected to the 1918 flu is because through time the virus would have made it&#039;s way to the brain damaging the movement part of the brain, which explains why it struck later in time after the 1918 pandemic. Which makes some since. If thats true than think of what would happen if the H5N1 (Avian Flu) Struck. Imagine what hell on earth would happen after it dissapears, with millions dead, then you get a second type of Encephalitis lethargica. One thats probably much worse. Also, add on the Encephalitis lethargica deaths to the total deaths of the 1918 pandemic. The new model says the the flu alone (not including Encephalitis lethargica) killed some 50-100 million people. Just as much as the black plauge. Aids has killed just as many people in 25 years as the Spanish Flu did in 25 weeks. A huge number. 
There&#039;s nothing we can do if H5N1 Strikes. You have to get the virus first then turn it into a vacine which takes some 2-3 months if I remember correctly, 2-3 months is time we don&#039;t have. We think were strong, at the top of the food chain (above animals, with technology) and yet we are wiped out and destroyed by something only microscopes can see. I wonder what we&#039;d do if the flu got out and took over major cities, quarentine the entire planet. It&#039;s waiting for the right time to strike, when humans are at their peak, secretly plotting it&#039;s revenge, like an assassin. One we can&#039;t see untill it&#039;s too late. Seems like some demonic enemy. One infection is all it takes, once it reaches schools, colleges, big cities, all hell breaks loose, by time we get a vacine it&#039;s too late, how will we distribute it, doctors and nurses first, older ones, those who need it most, riots and fights will break out, if it strikes armed forces, one by one they&#039;ll fall, where will we put the bodies. We&#039;ll be out of room, more deaths than the Spanish Flu and Black Death will be more than likely; considering how may humans live on this planet, A second type of Encephalitis lethargica stirkes those that survive. It&#039;s going to be one hell of party when it strikes. I feel bad for those that get killed by it, I hope i&#039;m one of them, I won&#039;t have to live the aftermath. What if your patient 0, the one responsible for the millions of deaths, you passed it on to them, how would you feel. Knowing that your the one who killed millions of inocent lives. Well, it&#039;s only a matter of time untill it attacks, getting it&#039;s revenge on the survivors, we had a large population in 1918, many died, those that survived-- repopulated and gave birth to more raising the number of lives. Ever noticed how when the number of humans is very large, disaster strikes; the black plauge killed 3/4 of Europe, 1918 pandemic killed just as may lives. The population is raising, when it&#039;s at it&#039;s peak the bar graph will drop. An ongoing patter, never ends untill all humans are dead. Sad thing is, if your within the ages of 0-40 and 65+ you&#039;ll be the first to go, those than are 16+ with active immune systems will most likely drown in your own blood. If you believe in god, some of us think why he does such things, after all he chooses who lives and dies and how.  But then again he has his reasons. Look on bright side, the 1918 flu led to many great advances in technology and research.</description>
		<content:encoded><![CDATA[<p>I watched a show about how the 1918 Flu Pandemic and Encephalitis lethargica  may be connected. It said the Encephalitis lethargica struck those that had the Spanish Flu but survived it. A huge Quarentine effort was put into effect in Sombolia and Encephalitis lethargica never showed up in that area but everywhere else it did. Also, it said the the Spanish Flu Pandemic rose hell on the same day in four different parts of the globe and vanished just as quick everywhere on the same day (in a different year of course). Pretty scary, almost seems like something out of this world. The reason they say Encephalitis lethargica is connected to the 1918 flu is because through time the virus would have made it&#8217;s way to the brain damaging the movement part of the brain, which explains why it struck later in time after the 1918 pandemic. Which makes some since. If thats true than think of what would happen if the H5N1 (Avian Flu) Struck. Imagine what hell on earth would happen after it dissapears, with millions dead, then you get a second type of Encephalitis lethargica. One thats probably much worse. Also, add on the Encephalitis lethargica deaths to the total deaths of the 1918 pandemic. The new model says the the flu alone (not including Encephalitis lethargica) killed some 50-100 million people. Just as much as the black plauge. Aids has killed just as many people in 25 years as the Spanish Flu did in 25 weeks. A huge number.<br />
There&#8217;s nothing we can do if H5N1 Strikes. You have to get the virus first then turn it into a vacine which takes some 2-3 months if I remember correctly, 2-3 months is time we don&#8217;t have. We think were strong, at the top of the food chain (above animals, with technology) and yet we are wiped out and destroyed by something only microscopes can see. I wonder what we&#8217;d do if the flu got out and took over major cities, quarentine the entire planet. It&#8217;s waiting for the right time to strike, when humans are at their peak, secretly plotting it&#8217;s revenge, like an assassin. One we can&#8217;t see untill it&#8217;s too late. Seems like some demonic enemy. One infection is all it takes, once it reaches schools, colleges, big cities, all hell breaks loose, by time we get a vacine it&#8217;s too late, how will we distribute it, doctors and nurses first, older ones, those who need it most, riots and fights will break out, if it strikes armed forces, one by one they&#8217;ll fall, where will we put the bodies. We&#8217;ll be out of room, more deaths than the Spanish Flu and Black Death will be more than likely; considering how may humans live on this planet, A second type of Encephalitis lethargica stirkes those that survive. It&#8217;s going to be one hell of party when it strikes. I feel bad for those that get killed by it, I hope i&#8217;m one of them, I won&#8217;t have to live the aftermath. What if your patient 0, the one responsible for the millions of deaths, you passed it on to them, how would you feel. Knowing that your the one who killed millions of inocent lives. Well, it&#8217;s only a matter of time untill it attacks, getting it&#8217;s revenge on the survivors, we had a large population in 1918, many died, those that survived&#8211; repopulated and gave birth to more raising the number of lives. Ever noticed how when the number of humans is very large, disaster strikes; the black plauge killed 3/4 of Europe, 1918 pandemic killed just as may lives. The population is raising, when it&#8217;s at it&#8217;s peak the bar graph will drop. An ongoing patter, never ends untill all humans are dead. Sad thing is, if your within the ages of 0-40 and 65+ you&#8217;ll be the first to go, those than are 16+ with active immune systems will most likely drown in your own blood. If you believe in god, some of us think why he does such things, after all he chooses who lives and dies and how.  But then again he has his reasons. Look on bright side, the 1918 flu led to many great advances in technology and research.</p>
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		<title>By: Cathryn</title>
		<link>http://www.damninteresting.com/the-sleeping-sickness/#comment-11456</link>
		<dc:creator>Cathryn</dc:creator>
		<pubDate>Sun, 31 Dec 2006 07:34:21 +0000</pubDate>
		<guid isPermaLink="false">http://www.damninteresting.com/?p=627#comment-11456</guid>
		<description>&lt;p&gt;&lt;span class=&#039;quote&#039;&gt;Random5 said: &quot;Come on now, it was a fairly good one liner, and jokes about the opposite sex are a fact of life. Maybe you two are overreacting just a little bit?&quot;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;i dont think any of them are.&lt;/p&gt;</description>
		<content:encoded><![CDATA[<p><span class='quote'>Random5 said: &#8220;Come on now, it was a fairly good one liner, and jokes about the opposite sex are a fact of life. Maybe you two are overreacting just a little bit?&#8221;</span></p>
<p>i dont think any of them are.</p>
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