Sometimes the requirement of giving out a prize annually causes the prize committee to deal the accolades out on someone whose effects aren’t as intense as they’d hope.
Not the case with the 2005 Nobel Prize Laureates for Medicine. The prize was dealt to a pair of Australians chaps, Barry J. Marshall & J. Robin Warren, who theorized that stomach ulcers were not caused by stress as common thinking held, but rather by bacteria. To prove this contention, Barry drank a dose of the suspected microorganisms.
For his efforts not only did he get half a Nobel Prize, but a case of ulcers too.